In the treatment of the tuberculosis, the due consideration must be paid for the good
knowledge of resistance of the tuberculous agents.
In this study, we observed the relationship of the emergence of resistance to the
length of medication in each antituberculous agent separately, and also evaluation of the
reliability of the results of sensitivity test to clinical of the result of sensitivity test to
clinical manifestation has been checked.
1). For 56 pulmonary tuberculosis patients, mostly far advanced, and with cavitation
have been under the combined chemotherapy for considerable duration, the sensitivity of
the SM. PAS and INH of each taculated in the length of its medications.
This tablation revealed that
a) In early stage of medications, tendency of emergence of resistance is definitively
less in PAS compared with those in SM and INH.
b) But at last, after months medication all of three angents gained resistance in 100%
of cases.
2). For the evaluation of reliability test in clinical manifestation, 56 patients devided in
sensitive and resistant groups. and each group was checked in subjective symptoms and
X-Ray indings and tabulated by the scales of improve, no change and deterioration.
Form this observation, we found that.
a) In sensitive group, about 50% improve, 5% deteriorated and 45% no change.
b) In resistant group, about 10% improve, 25% deteriorate and 65% no change.
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